Kambô Peptides
The peptides identified in Kambô so far are as follows:
phyllocaerulein
Caerulein Family - a neuropeptide which produces strong smooth muscle contraction (heart, gut and vascular), reduces blood pressure, modifies satiety, sedation and thermoregulation. It is also a potent analgesic. During a Kambo treatment, it is this substance that is largely responsible for nausea, vomiting, palpitations, sweating and abdominal discomfort.
Phyllocaerulein stimulates the adrenal cortex and pituitary gland while causing gall bladder contractions and secretion of gastric and pancreatic juices. Phyllocaerulein and phyllokinnin contribute to hypotensive effects of kambo and why some people’s blood pressure drops, causing temporary fainting.
This family of peptides also contributes to the reduction of nociception, which is the sensory nervous system’s response to harmful stimuli. Hypothetically, this could give the nervous system a chance to reboot without the constant bombardment of stressful stimulation. Through its powerful analgesic properties, it diminishes pain and fatigue while increasing physical strength and resistance.
phyllokinin
Bradykinins Family - Relaxes smooth muscles. Potent vasodilator, increasing permeability of blood-brain barrier. Long lasting reduction in blood pressure.
phyllomedusin
tachykinins family
a neuropeptide which strongly affects the salivary glands, tear ducts, intestines and bowels. It’s a powerful Vasodilator which stimulates gastric secretions and contributes to violent purging and defecation. The fast dilation of the blood vessels causes the ‘rushing’ or ‘pounding’ sensation that Kambo sometimes produces.
Phyllomedusin regulates functions of dopamine, serotonin, and other neurotransmitters. Contracts smooth muscles. Potent vasodilator, increasing permeability of blood-brain barrier. Powerful effect on intestines and bowels, contributing to the purging of toxins.
phyllolitorin
[Leu8] Phyllolitorin, Rohdei-Litorin – Bombesins Family - neuropeptides that are active in the central and peripheral nervous system, stimulate gastric acid secretion and smooth muscle contraction
dermorphin
Sauvagine Family – a heptapeptide with a potent opiate-like activity on mu-type opioid receptors, which have potent depressive and analgesic effects. Dermorphin may also have effects on pulmonary ventilation and pituitary hormone release and is 30-40 times more potent than Morphine.
Sauvagine functions like a hormone, interacting with the pituitary-adrenal axis and corticotropin- releasing receptors, which are involved in cortisol, stress, anxiety, depression, and addictive behaviors. It also holds properties that affect smooth muscle contraction of the colon and urinary bladder, alongside tachycardia and reduction in blood pressure.” - Kambo International Source
deltorphin
Deltorphin Family – a heptapeptide, which has a higher affinity and selectivity for delta opioid binding sites than any other natural compound known. Two Deltorphins have been discovered in the secretion of Phyllomedusa Bicolor
tryptophyllins
biological activity somewhat obscure but recently found to be highly potent against the yeast Candida Albicans, Potential in cardiovascular, inflammatory, and anti-cancer therapy
dermaseptin
Dermaseptin Family – potent antimicrobial activity against bacteria, yeast, fungi, protozoa and enveloped viruses as well as various filamentous fungi that are responsible for severe opportunistic infections accompanying AIDS and the use of immunosuppressive agents. Adenoregulin (also named Dermaseptin B2) is a 33 amino acid peptide that interacts with the adenosine receptor, a fundamental component in all human cell fuel and has shown effectiveness in killing cancer cells.
Dermaseptins have incredible antibiotic activity and have been found to be effective against bacteria, viruses, fungi, and protozoa. Studies have explored dermaseptins ability to destroy on contact pathogens such as E.coli, salmonella, gonorrhea, herpes viruses, HIV, candida albicans, and even malaria-causing protozoans. Dermaseptins have a promising future as medications given their ability to kill pathogens selectively without harming animal cells